{"id":6906,"date":"2017-05-18T08:11:24","date_gmt":"2017-05-18T08:11:24","guid":{"rendered":"https:\/\/sibutramine-reductil.info\/lhistoire-de-reductil\/"},"modified":"2025-05-06T13:31:08","modified_gmt":"2025-05-06T13:31:08","slug":"lhistoire-de-reductil","status":"publish","type":"page","link":"https:\/\/sibutramine-reductil.info\/fr\/lhistoire-de-reductil\/","title":{"rendered":"L’histoire de Reductil"},"content":{"rendered":"

[et_pb_section fb_built=\u00a0\u00bb1″ admin_label=\u00a0\u00bbSection\u00a0\u00bb _builder_version=\u00a0\u00bb3.22″ background_image=\u00a0\u00bbhttps:\/\/sibutramine-reductil.info\/wp-content\/uploads\/2017\/05\/background-title.jpg\u00a0\u00bb transparent_background=\u00a0\u00bboff\u00a0\u00bb make_fullwidth=\u00a0\u00bboff\u00a0\u00bb use_custom_width=\u00a0\u00bboff\u00a0\u00bb width_unit=\u00a0\u00bbon\u00a0\u00bb][et_pb_row admin_label=\u00a0\u00bbRang\u00e9e\u00a0\u00bb _builder_version=\u00a0\u00bb3.25″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb make_fullwidth=\u00a0\u00bboff\u00a0\u00bb use_custom_width=\u00a0\u00bboff\u00a0\u00bb width_unit=\u00a0\u00bbon\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb3.25″ custom_padding=\u00a0\u00bb|||\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbThe History Of Reductil\u00a0\u00bb _builder_version=\u00a0\u00bb3.27.4″ header_font=\u00a0\u00bbMontserrat|on|||\u00a0\u00bb header_text_color=\u00a0\u00bb#ffffff\u00a0\u00bb header_font_size=\u00a0\u00bb40px\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]<\/p>\n

L’histoire de Reductil<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ admin_label=\u00a0\u00bbSection\u00a0\u00bb _builder_version=\u00a0\u00bb3.22″ background_color=\u00a0\u00bb#32cd32″ background_image=\u00a0\u00bbhttps:\/\/sibutramine-reductil.info\/wp-content\/uploads\/2017\/05\/dots-white-bigger-1.png\u00a0\u00bb custom_css_main_element=\u00a0\u00bbbackground-position: initial;||background-size: initial;||background-repeat: repeat;\u00a0\u00bb transparent_background=\u00a0\u00bboff\u00a0\u00bb make_fullwidth=\u00a0\u00bboff\u00a0\u00bb use_custom_width=\u00a0\u00bboff\u00a0\u00bb width_unit=\u00a0\u00bbon\u00a0\u00bb][et_pb_row column_structure=\u00a0\u00bb1_3,2_3″ admin_label=\u00a0\u00bbRang\u00e9e\u00a0\u00bb _builder_version=\u00a0\u00bb3.25″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb make_fullwidth=\u00a0\u00bboff\u00a0\u00bb use_custom_width=\u00a0\u00bboff\u00a0\u00bb width_unit=\u00a0\u00bbon\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb3.25″ custom_padding=\u00a0\u00bb|||\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sibutramine-reductil.info\/wp-content\/uploads\/2024\/03\/atech-REDUCTIL-1-150×150.jpg\u00a0\u00bb title_text=\u00a0\u00bbatech-REDUCTIL-1″ align=\u00a0\u00bbcenter\u00a0\u00bb align_tablet=\u00a0\u00bbcenter\u00a0\u00bb align_phone=\u00a0\u00bb\u00a0\u00bb align_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb admin_label=\u00a0\u00bbImage\u00a0\u00bb _builder_version=\u00a0\u00bb4.6.1″ animation_style=\u00a0\u00bbslide\u00a0\u00bb animation_direction=\u00a0\u00bbleft\u00a0\u00bb animation_duration=\u00a0\u00bb500ms\u00a0\u00bb animation_intensity_slide=\u00a0\u00bb10%\u00a0\u00bb hover_enabled=\u00a0\u00bb0″ custom_css_main_element=\u00a0\u00bbborder: 5px solid; ||border-radius: 300px;||border-color: #32CD32;||padding: 30px;||background-color: white;\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb animation=\u00a0\u00bbleft\u00a0\u00bb sticky=\u00a0\u00bboff\u00a0\u00bb always_center_on_mobile=\u00a0\u00bbon\u00a0\u00bb sticky_enabled=\u00a0\u00bb0″][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb2_3″ _builder_version=\u00a0\u00bb3.25″ custom_padding=\u00a0\u00bb|||\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb3.27.4″ text_font=\u00a0\u00bbArial||||\u00a0\u00bb text_text_color=\u00a0\u00bb#000000″ text_font_size=\u00a0\u00bb17″ text_line_height=\u00a0\u00bb1.8em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]Bucket et d’autres chercheurs ont d\u00e9couvert la \u00ab\u00a0formule\u00a0\u00bb mol\u00e9culaire originale <\/strong>de la sibutramine en 1987 ; on a d’abord <\/strong>pens\u00e9 que ce produit pourrait \u00eatre utilis\u00e9 efficacement<\/strong> comme antid\u00e9presseur.<\/p>\n

Ce raisonnement s’est av\u00e9r\u00e9 tr\u00e8s perspicace<\/strong>, car la <\/strong>sibutramine augmente les niveaux de s\u00e9rotonine, ce qui favorise l’am\u00e9lioration de l’humeur.<\/p>\n

Boots of Nottingham UK a commenc\u00e9 \u00e0 d\u00e9velopper la<\/strong> sibutramine et \u00e0 affiner sa structure<\/strong> avant de l’administrer \u00e0 des sujets d’exp\u00e9rience en 1988 - pendant les deux ann\u00e9es suivantes, elle a \u00e9t\u00e9 soumise \u00e0 des tests rigoureux <\/strong>sur le terrain.
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ admin_label=\u00a0\u00bbSection\u00a0\u00bb _builder_version=\u00a0\u00bb3.22″ background_image=\u00a0\u00bbhttps:\/\/sibutramine-reductil.info\/wp-content\/uploads\/2017\/05\/cement-texture-with-spots_1154-573.jpg\u00a0\u00bb custom_css_main_element=\u00a0\u00bbbackground-position: initial;||background-size: initial;||background-repeat: repeat;\u00a0\u00bb transparent_background=\u00a0\u00bboff\u00a0\u00bb make_fullwidth=\u00a0\u00bboff\u00a0\u00bb use_custom_width=\u00a0\u00bboff\u00a0\u00bb width_unit=\u00a0\u00bbon\u00a0\u00bb][et_pb_row admin_label=\u00a0\u00bbRang\u00e9e\u00a0\u00bb _builder_version=\u00a0\u00bb3.25″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb custom_css_main_element=\u00a0\u00bbborder: 1px solid;||border-color: #32CD32;||padding: 30px;||padding-top: -50px !important;||background-image: url(https:\/\/sibutramine-reductil.info\/wp-content\/uploads\/2017\/05\/dots-white-bigger-1.png);||\u00a0\u00bb make_fullwidth=\u00a0\u00bboff\u00a0\u00bb use_custom_width=\u00a0\u00bboff\u00a0\u00bb width_unit=\u00a0\u00bbon\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb3.25″ custom_padding=\u00a0\u00bb|||\u00a0\u00bb custom_padding__hover=\u00a0\u00bb|||\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbText\u00a0\u00bb _builder_version=\u00a0\u00bb3.27.4″ text_font=\u00a0\u00bbArial||||\u00a0\u00bb text_text_color=\u00a0\u00bb#000000″ text_font_size=\u00a0\u00bb16″ text_line_height=\u00a0\u00bb1.8em\u00a0\u00bb background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb use_border_color=\u00a0\u00bboff\u00a0\u00bb border_color=\u00a0\u00bb#ffffff\u00a0\u00bb border_style=\u00a0\u00bbsolid\u00a0\u00bb]\"\"Les r\u00e9sultats concernant l’\u00e9l\u00e9vation de l’humeur \u00e9taient positifs<\/strong>, mais ce n’est qu’en 1990 - lorsqu’un brevet a \u00e9t\u00e9 d\u00e9pos\u00e9 par Kiyoharu Ukai et d’autres, faisant \u00e9tat de la capacit\u00e9 de la sibutramine <\/a>\u00e0 avoir un impact positif sur les troubles de la fonction c\u00e9r\u00e9brale<\/strong> - que le monde m\u00e9dical a commenc\u00e9 \u00e0 appr\u00e9cier le fait que la sibutramine \u00e9tait capable de faire plus que la somme de ses parties<\/a>.<\/p>\n

Ind\u00e9pendamment de ce brevet, la sibutramine a continu\u00e9 \u00e0 <\/strong>faire l’objet de tests approfondis et d’un d\u00e9veloppement plus pouss\u00e9<\/strong> au cours des cinq ann\u00e9es suivantes en tant qu’antid\u00e9presseur. Ce qui a le plus frapp\u00e9<\/strong> les chercheurs de l’\u00e9poque, c’est que ce m\u00e9dicament n’entra\u00eenait aucune <\/strong>fluctuation de l’humeur, contrairement aux antid\u00e9presseurs habituels. <\/p>\n

Les niveaux constamment \u00e9lev\u00e9s<\/a><\/strong> Les niveaux de s\u00e9rotonine pr\u00e9sents dans le corps lors de l’utilisation de ce produit ont conduit de nombreuses personnes <\/strong>\u00e0 penser qu’il pourrait s’agir d’un moyen presque \u00ab\u00a0parfait\u00a0\u00bb<\/strong> de contr\u00f4ler la d\u00e9pression \/ d’int\u00e9grer un afflux constant d’humeur positive et d’\u00e9nergie<\/strong> chez les personnes souffrant d’affections qui drainent les r\u00e9serves de<\/strong> s\u00e9rotonine disponibles<\/strong> ou de la r\u00e9gulation de sa lib\u00e9ration.<\/strong><\/p>\n

Apr\u00e8s avoir rachet\u00e9 la division de recherche de Boots en 1995, Knoll Pharmaceuticals<\/a> a continu\u00e9 \u00e0 <\/strong>effectuer des tests et c’est par hasard qu’<\/strong> ils ont d\u00e9couvert que les patients ob\u00e8ses utilisant la sibutramine perdaient en fait perdaient des quantit\u00e9s significatives de poids<\/a><\/strong>.<\/p>\n

C’est ce qui a finalement <\/strong>conduit \u00e0 l’administrer \u00e0 des patients ob\u00e8ses comme aide \u00e0 la perte de poids , ind\u00e9pendamment de<\/strong> ses propri\u00e9t\u00e9s antid\u00e9pressives. Cette derni\u00e8re utilisation est d’ailleurs rapidement tomb\u00e9e en d\u00e9su\u00e9tude pour des raisons indiscernables. <\/p>\n

Il semble qu’il n’y ait aucun document \u00ab\u00a0officiel\u00a0\u00bb sur la logique qui sous-tend l’arr\u00eat de<\/strong> l’utilisation de ce m\u00e9dicament dans le <\/strong>cadre d’un traitement antid\u00e9presseur. Il s’est r\u00e9ellement av\u00e9r\u00e9 efficace<\/strong> dans ce domaine - certains disent que c’est peut-\u00eatre simplement d\u00fb \u00e0 un manque de recherches suppl\u00e9mentaires<\/strong> ou de preuves solides corr\u00e9l\u00e9es d’une mani\u00e8re suffisamment convaincante<\/strong>. <\/p>\n

Les rapports d’essais, par exemple, n’ont jamais \u00e9t\u00e9 publi\u00e9s officiellement <\/strong>, ce qui aura sans doute nui \u00e0 sa \u00ab\u00a0l\u00e9gitimit\u00e9\u00a0\u00bb.<\/p>\n

La circulation \u00ab\u00a0officielle\u00a0\u00bb de sibutramine \u00e0 des fins de perte de poids<\/a><\/strong> a commenc\u00e9 en 1997, lorsque la FDA a autoris\u00e9 son utilisation pour les personnes consid\u00e9r\u00e9es comme cliniquement ob\u00e8ses en<\/strong> tant qu’aide \u00e0 la perte de poids.<\/p>\n

\u00c0 bien des \u00e9gards, ce sont ces condol\u00e9ances \u00ab\u00a0officielles\u00a0\u00bb qui ont contribu\u00e9 \u00e0 ouvrir la voie <\/em>\u00e0 des proc\u00e9dures populaires de nos jours, comme la pose d’un anneau gastrique. C’\u00e9tait la premi\u00e8re fois que<\/strong> la population ob\u00e8se disposait d’un moyen relativement \u00ab\u00a0discret\u00a0\u00bb (c’est du moins ce que pensait le corps m\u00e9dical \u00e0 l’\u00e9poque) de contr\u00f4ler le<\/strong> taux de graisse corporelle<\/strong>. <\/p>\n

Knoll Pharma, sous les noms de Reductil et Meridia, a distribu\u00e9 ce \u00ab\u00a0rem\u00e8de\u00a0\u00bb - ces noms \u00ab\u00a0communs\u00a0\u00bb sont devenus les noms commerciaux les plus connus pour la sibutramine.<\/p>\n

Il a \u00e9t\u00e9 largement utilis\u00e9<\/strong> comme aide \u00e0 la perte de poids pr\u00e9tendument \u00ab\u00a0s\u00fbre\u00a0\u00bb jusqu’en janvier 2003, date \u00e0 laquelle une vaste \u00e9tude intitul\u00e9e \u00ab\u00a0Sibutramine Cardiovascular Outcomes\u00a0\u00bb a \u00e9t\u00e9 r\u00e9alis\u00e9e et s’est poursuivie jusqu’en novembre 2005.<\/p>\n

10 742 patients ont \u00e9t\u00e9 examin\u00e9s <\/strong>au cours de cette p\u00e9riode, et le r\u00e9sultat final a \u00e9t\u00e9 que la sibutramine avait un rapport de risque de 1,16 en ce qui concerne les effets ind\u00e9sirables. de produire des effets ind\u00e9sirables<\/a><\/strong> de la fonction cardiovasculaire\/art\u00e9rielle.<\/p>\n

Ce rapport de risque a \u00e9t\u00e9 jug\u00e9 beaucoup trop \u00e9lev\u00e9<\/strong> pour que le reductil puisse continuer \u00e0 \u00eatre distribu\u00e9 dans le but de lutter contre l’ob\u00e9sit\u00e9<\/strong>. C’est pourquoi Knoll et tous les autres grands fabricants l ‘ont compl\u00e8tement retir\u00e9 du march\u00e9<\/strong> et il a \u00e9t\u00e9 rel\u00e9gu\u00e9 au \u00ab\u00a0purgatoire\u00a0\u00bb des m\u00e9dicaments (\u00e0 des fins de test uniquement, voire jamais) par la suite. <\/p>\n

\"\"Il est int\u00e9ressant (et plut\u00f4t juste) de noter que David Haslam, le pr\u00e9sident du National Obesity Forum<\/a>, a soulign\u00e9 que les \u00e9tudes r\u00e9alis\u00e9es sur le reductil dans le cadre de la proc\u00e9dure \u00ab\u00a0SCOUT\u00a0\u00bb \u00e9taient toutes biais\u00e9es<\/strong> car elles avaient \u00e9t\u00e9 men\u00e9es sur des patients pr\u00e9sentant des pr\u00e9dispositions m\u00e9dicales li\u00e9es sp\u00e9cifiquement aux effets ind\u00e9sirables potentiels<\/a><\/strong> de l’utilisation du reductil.<\/p>\n

Cela signifierait par d\u00e9faut<\/strong> que les effets secondaires<\/a> \u00e9taient presque garantis de se produire<\/strong> \u00e0 intervalles r\u00e9guliers au cours des essais. Il n’est pas certain que cette forme de test<\/strong> apparemment biais\u00e9e<\/strong> ait \u00e9t\u00e9 d\u00e9ploy\u00e9e intentionnellement ou non, mais elle a<\/strong> certainement abouti \u00e0 un r\u00e9sultat n\u00e9gatif<\/strong> pour la distribution de ce produit. <\/p>\n

Il est assez \u00e9trange<\/strong> que le reductil <\/a>fasse l’objet d’une telle critique<\/strong> alors que d’autres <\/strong>m\u00e9dicaments, en particulier les hormones thyro\u00efdiennes, n’ont pas \u00e9t\u00e9 examin\u00e9s<\/strong> pour leurs effets potentiellement n\u00e9fastes sur l’organisme.<\/p>\n

La T3 est sans doute beaucoup plus dangereuse<\/strong> que le reductil en ce qui concerne les effets ind\u00e9sirables chez les utilisateurs - la diff\u00e9rence \u00e9tant que les deux <\/strong>m\u00e9dicaments ont \u00e9t\u00e9 d\u00e9ploy\u00e9s \u00e0 des fins totalement diff\u00e9rentes.<\/strong><\/p>\n

N\u00e9anmoins, le fait que l’un continue \u00e0 \u00eatre distribu\u00e9 \u00e0 grande \u00e9chelle et que l’autre ne le soit pas est une sorte de contradiction d’int\u00e9r\u00eats<\/strong>.<\/p>\n

Il serait peut-\u00eatre judicieux<\/strong> d’examiner la s\u00e9curit\u00e9 de la sibutramine dans des conditions contr\u00f4l\u00e9es<\/strong> (o\u00f9 tous les patients seraient \u00ab\u00a0neutres\u00a0\u00bb et ne<\/strong> souffriraient d’aucune contre-indication existante<\/strong> li\u00e9e aux effets ind\u00e9sirables de la sibutramine, pour commencer…).<\/p>\n

Jusqu’\u00e0 ce jour, le seul moyen d’acqu\u00e9rir ce produit sera de passer par les UGL (UnderGround Laboratories).<\/a>
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